Chronic pain costs the economy $600 billion a year and the two most common treatments have significant drawbacks: narcotics are addictive, and surgery is costly and carries considerable risks.
Ada Poon, a Stanford assistant professor of electrical engineering, is a master at building miniscule wireless devices that function in the body and can be powered remotely. She and collaborators in bioengineering and anesthesia want to leverage this technology to develop a way of studying, and eventually developing treatments for, pain.
The new endeavor builds on work by Scott Delp, professor of bioengineering and mechanical engineering, and his students Kate Montgomery, who is a Bio-X fellow, and Shrivats Iyer. They developed a way of using light to control the activity of neurons that transmit pain, taking advantage of a technique called optogenetics. One color of light stopped the nerve from firing and prevented pain. Another color caused the nerve to fire.
The work involved genetically engineering nerves in mice to be responsive to light, and is therefore not something that can be done in humans. But it did point to a new way of studying how the sensation of pain is transmitted to and from the brain and, potentially, developing or testing better therapies.
Despite promise as a new model for studying pain, the initial approach had limitations. Since the light came through a cumbersome fiber optic cable, the mice couldn’t move freely or use exercise wheels. It wasn’t a natural environment and so any insights might not be relevant to humans.
“Right now, the only way to study pain is an indirect method,” Poon said. And that indirect method has so for not been successful in generating new therapies.
Chronic pain costs the economy $600 billion a year and the two most common treatments have significant drawbacks: narcotics are addictive, and surgery is costly and carries considerable risks.“We’ve had failure after failure to translate drugs that were successful in animals to humans,” said David Clark, a professor of anesthesiology and pain management who treats patients with chronic pain in his medical practice. “This puts a premium on understanding how we should be studying pain.”
Coupling a wireless technology to optogenetics eliminates the wire and allows a mouse to move freely, use an exercise wheel and socialize. This combination, Clark argues, will allow researchers to design experiments that more closely mirror a patient’s experience.
“What we will be able to look at is a more natural measure of pain relief,” Poon added. They could assess whether a treatment allows mice to return to normal activities by tallying time spent on an exercise wheel or socializing.
This collaboration is one of 22 projects recently funded by the Stanford Bio-X Seed grants, which Carla Shatz, the director of Bio-X, calls the “glue” that brings interdisciplinary teams together. The project is typical, with an electrical engineer, a bioengineer and an anesthesiologist, all of whom are Bio-X affiliates, working together to solve a biomedical problem. Bio-X has so far brought together more than 600 interconnected faculty members from across campus.